Advances and Breakthroughs in IRES-Directed Translation and Replication of Picornaviruses
Sahibzada Waheed Abdullah, Jin’en Wu, Xuefei Wang, Huichen Guo, Shiqi Sun
Abstract
, past and present discoveries regarding ITAFs, and their mechanism of action. The herbal extracts, drugs, and chemicals, which indicated their importance in controlling viruses, were also summarized. In addition, we discussed the movement of ITAFs from the nucleus to viral replication factories. We believe this review will stimulate researchers to search for more novel ITAFs, drugs, herbal extracts, and chemicals, enhancing the understanding of virus-host interaction.
Topics & Concepts
Internal ribosome entry sitePicornavirusPicornaviridaeBiologyTranslation (biology)VirologyEukaryotic translationViral replicationGeneticsComputational biologyPoliovirusNucleic acid structureRNAVirusGeneMessenger RNAViral Infections and Immunology ResearchRNA and protein synthesis mechanismsRNA Research and Splicing