Rational design of tumor-selective prodrug nanoassemblies: Greatly improving the in vivo fate and tolerability of high-toxic cabazitaxel
Jingxuan Zhang, Yu Zhang, Yuetong Huang, Danping Wang, Shiyi Zuo, Hezhen Xu, Zhonggui He, Qiming Kan, Xiaohong Liu, Bingjun Sun, Jin Sun
Topics & Concepts
ProdrugChemistryPaclitaxelTaxanePharmacologyDocetaxelCabazitaxelCytotoxicityIn vivoPharmacokineticsToxicityRational designBioavailabilityIn vitroChemotherapyBiochemistryCancerNanotechnologyOrganic chemistryMedicineBiologyMaterials scienceBiotechnologyProstate cancerAndrogen deprivation therapyBreast cancerSurgeryInternal medicineNanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryDendrimers and Hyperbranched Polymers