Highlights of the Recent Patent Literature: Focus on Asymmetric Organocatalysis
David L. Hughes
Abstract
This review explores contributions in asymmetric organocatalysis from the patent literature since 2018, including reactions catalyzed by Cinchona alkaloids as free base and quaternary salts, phosphonium salts, proline-derived catalysts, and chiral phosphoric acids. Examples of processes employing asymmetric organocatalysis for the industrial preparation of pharmaceutical intermediates are highlighted.
Topics & Concepts
OrganocatalysisChemistryPhosphoniumCinchonaOrganic chemistryEnantioselective synthesisCatalysisPhosphoric acidCombinatorial chemistryAsymmetric Synthesis and CatalysisAsymmetric Hydrogenation and CatalysisChemical Synthesis and Analysis