Diazotization-Enabled Deaminative Late-Stage Functionalization of Primary Sulfonamides
Jiang‐Sheng Li, Jia Liu, Yao-Tian Wang, Jia‐Ying Dai, Zhiwei Li, Weiwei Luo, Yue‐Fei Zhang, Hanwen Liu, Weidong Liu
Abstract
We, for the first time, disclosed a simple and efficient strategy for the late-stage functionalization of primary sulfonamides by diazotization, leading to sulfonyl chlorides, sulfonates, and complex sulfonamides. This protocol obviates the requirement for the prefunctionalization of sulfonamides. Its applicability is exemplified by the late-stage functionalization of sulfonamide-type drugs.
Topics & Concepts
Surface modificationChemistrySulfonamideSulfonylCombinatorial chemistryPrimary (astronomy)Organic chemistryAstronomyAlkylPhysicsPhysical chemistrySulfur-Based Synthesis TechniquesSynthesis and Catalytic ReactionsCyclopropane Reaction Mechanisms