Conserved anti-inflammatory effects and sensing of butyrate in zebrafish
Pradeep Manuneedhi Cholan, Alvin Han, Brad R. Woodie, Maxinne Watchon, Angela R.M. Kurz, Angela S. Laird, Warwick J. Britton, Lihua Ye, Zachary C. Holmes, Jessica R. McCann, Lawrence A. David, John F. Rawls, Stefan H. Oehlers
Abstract
) gene. Neutrophils from Hcar1-depleted embryos were no longer responsive to the anti-inflammatory effects of butyrate, while macrophage sensitivity to butyrate was independent of Hcar1. Our data demonstrate conservation of anti-inflammatory butyrate effects and identify the presence of a conserved molecular receptor in fish.
Topics & Concepts
ButyrateZebrafishBiologyPropionateDysbiosisIn vivoMicrobiomeImmune systemInflammationGut floraCell biologyMicrobiologyBiochemistryFermentationImmunologyGeneGeneticsGut microbiota and healthEpigenetics and DNA MethylationImmune cells in cancer