A Major Facilitator Superfamily (MFS) Efflux Pump, SCO4121, from Streptomyces coelicolor with Roles in Multidrug Resistance and Oxidative Stress Tolerance and Its Regulation by a MarR Regulator
Ankita Nag, Sarika Mehra
Abstract
One of the key mechanisms of drug resistance in bacteria is overexpression of efflux pumps. Streptomyces species are a reservoir of a large number of efflux pumps, potentially to provide resistance to both endogenous and nonendogenous antibiotics. While many of these pumps are not expressed under standard laboratory conditions, they result in resistance to multiple drugs when spread to other bacterial pathogens through horizontal gene transfer.
Topics & Concepts
EffluxMajor facilitator superfamilyStreptomyces coelicolorMultiple drug resistanceRegulatorBiologyMicrobiologyDrug resistanceStreptomycesBacteriaATP-binding cassette transporterGeneGeneticsTransporterAntibiotic Resistance in BacteriaCancer therapeutics and mechanismsMycobacterium research and diagnosis