Input-specific regulation of glutamatergic synaptic transmission in the medial prefrontal cortex by mGlu <sub>2</sub> /mGlu <sub>4</sub> receptor heterodimers
Zixiu Xiang, Xiaohui Lv, Xin Lin, Daniel E. O’Brien, Molly K. Altman, Craig W. Lindsley, Jonathan A. Javitch, Colleen M. Niswender, P. Jeffrey Conn
Abstract
heterodimers inhibited glutamatergic signaling at thalamo-mPFC synapses but not at hippocampus-mPFC or amygdala-mPFC synapses. These findings raise the possibility that selectively targeting these heterodimers could be a therapeutic strategy for some neurologic and neuropsychiatric disorders involving specific brain circuits.
Topics & Concepts
GlutamatergicPrefrontal cortexNeuroscienceMetabotropic glutamate receptorGlutamate receptorMetabotropic receptorNeurotransmissionReceptorBiologyChemistryBiochemistryCognitionNeuroscience and Neuropharmacology ResearchPhotoreceptor and optogenetics researchMemory and Neural Mechanisms