Engineering Bacteria as Living Therapeutics in Cancer Therapy
Jiangfeng Chen, Jiaqi Chen, Yixuan Chen, Wenxuan Yuan, Jiao Zhang, Guoqing Wang, Zhuojun Dai
Abstract
Cancer is the second-leading cause of death globally, yet traditional therapies like chemotherapy face significant limitations. Recent advances in synthetic biology enable the design of various genetic circuits and the reprogramming of biological systems. Collectively, these efforts have led to the repurposing of engineered bacteria as therapeutics to achieve tumor targeting, tumor microenvironment modulation, and anticancer drug release. Here, these recent efforts are reviewed and discussed the challenges and future opportunities.
Topics & Concepts
RepurposingReprogrammingCancer therapyDrug repositioningSynthetic biologyCancerTumor microenvironmentMedicineComputational biologyBiologyDrugPharmacologyInternal medicineCellGeneticsEcologyCancer Research and Treatments3D Printing in Biomedical ResearchNanoplatforms for cancer theranostics