Engineered probiotics biofilm enhances osseointegration via immunoregulation and anti-infection
Lei Tan, Jieni Fu, Fan Feng, Xiangmei Liu, Zhenduo Cui, Bo Li, Yong Han, Yufeng Zheng, Kwk Yeung, Zhaoyang Li, Shengli Zhu, Yanqin Liang, Xiaobo Feng, Xianbao Wang, Shuilin Wu
Abstract
biofilm stimulate macrophages to secrete abundant osteogenic cytokines such as oncostatin M and improve osseointegration of the Ti implant. Inactivated probiotics modification can be a promising strategy to endow implants with both excellent self-antibacterial activity and osteointegration ability.
Topics & Concepts
OsseointegrationBiofilmMicrobiologyImmunologyBiologyMedicineBacteriaImplantSurgeryGeneticsCancer Research and TreatmentsBone Tissue Engineering MaterialsOrthopedic Infections and Treatments