Influenza A H1N1 Induced Disturbance of the Respiratory and Fecal Microbiome of German Landrace Pigs – a Multi-Omics Characterization
Laurin Christopher Gierse, Alexander Meene, Daniel Schultz, Theresa Schwaiger, Charlotte Schröder, Pierre Mücke, Daniela Zühlke, Tjorven Hinzke, Haitao Wang, Karen Methling, Bernd Kreikemeyer, Jörg Bernhardt, Dörte Becher, Thomas C. Mettenleiter, Michael Lalk, Tim Urich, Katharina Riedel
Abstract
Here, we used swine as a biomedical model to elucidate the impact of influenza A H1N1 infection on structure and function of the respiratory and gastrointestinal tract microbiome by employing a multi-omics analytical approach. To our knowledge, this is the first study to investigate the temporal development of the porcine microbiome and to provide insights into the functional capacity of the gastrointestinal microbiome during influenza A virus infection.
Topics & Concepts
MicrobiomeDisturbance (geology)Fecal bacteriotherapyBiologyFecesGermanCoronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakMicrobiologyVirologyMedicineBioinformaticsDiseaseInternal medicineGeographyOutbreakInfectious disease (medical specialty)AntibioticsPaleontologyArchaeologyClostridium difficileGut microbiota and healthAnimal Nutrition and PhysiologyViral gastroenteritis research and epidemiology