α-Lactalbumin peptide Asp-Gln-Trp alleviates hepatic insulin resistance and modulates gut microbiota dysbiosis in high-fat diet-induced NAFLD mice
Haoran Chen, Yue Sun, Haiding Zhao, Xiaofen Qi, Hui Cui, Qiming Li, Ying Ma
Abstract
further proved that the effects of DQW on the attenuation of hepatic insulin resistance were mediated by the PPARα and IRS1/PI3K/AKT pathways. Taken together, these results indicated that DQW treatment could attenuate HFD-induced NAFLD and insulin resistance by modulating gut microbiota composition, enhancing the SCFA levels, and activating the PPARα and IRS1/PI3K/Akt pathways.
Topics & Concepts
Insulin resistanceDysbiosisGut floraInternal medicineEndocrinologyLachnospiraceaeBacteroidesBiologyFatty liverSteatosisDyslipidemiaNonalcoholic fatty liver diseaseInsulinFirmicutesMedicineImmunologyBiochemistryDiabetes mellitusBacteriaGeneDisease16S ribosomal RNAGeneticsGut microbiota and healthDiet and metabolism studiesLiver Disease Diagnosis and Treatment