Multimodal imaging of capsid and cargo reveals differential brain targeting and liver detargeting of systemically-administered AAVs
Jai Woong Seo, Javier Ajenjo, Bo Wu, Elise Robinson, Marina N. Raie, James Wang, Spencer K. Tumbale, Pablo Buccino, David Anders, Bin Shen, Frezghi Habte, Corinne Beinat, Michelle L. James, Samantha T. Reyes, Sripriya Ravindra Kumar, Timothy F. Miles, Jason T. Lee, Viviana Gradinaru, Katherine W. Ferrara
Topics & Concepts
Transduction (biophysics)CapsidReporter geneGene deliveryGenetic enhancementAdeno-associated virusCell biologyMolecular biologyBiologyGeneBiophysicsGene expressionRecombinant DNAVector (molecular biology)BiochemistryVirus-based gene therapy researchRNA Interference and Gene DeliveryCRISPR and Genetic Engineering