Enhancing siRNA efficacy in vivo with extended nucleic acid backbones
Ken Yamada, Vignesh Hariharan, Jillian Caiazzi, Rachael Miller, Chantal Ferguson, Ellen Sapp, Hassan H. Fakih, Qi Tang, Nozomi Yamada, Raymond Furgal, Joseph Paquette, Annabelle Biscans, Brianna Bramato, Nicholas McHugh, Ashley Summers, Clemens Lochmann, Bruno M.D.C. Godinho, Samuel Hildebrand, S Jackson, Dimas Echeverria, Matthew Hassler, Julia F. Alterman, Marian DiFiglia, Neil Aronin, Anastasia Khvorova
Topics & Concepts
Phosphodiester bondOligonucleotideNucleaseNucleic acidSmall interfering RNARNAExonucleaseLocked nucleic acidBiochemistryChemistryIn vivoMolecular biologyBiologyDNAGenePolymeraseBiotechnologyAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryDNA and Nucleic Acid Chemistry