Prodrug-loaded semiconducting polymer hydrogels for deep-tissue sono-immunotherapy of orthotopic glioblastoma
Liyun Zhu, Xing Wang, Mengbin Ding, Ningyue Yu, Yijing Zhang, Hongwei Wu, Qin Zhang, Jiansheng Liu, Jingchao Li
Abstract
-cleavable linkers to precisely activate the NLG919 prodrug. Antitumor immunity is significantly amplified due to the reversal of immunosuppression mediated by indolamine 2,3-dioxygenase-dependent tryptophan metabolism. This smart prodrug hydrogel platform potently inhibits tumor growth in orthotopic glioma-bearing mice. Collectively, this work provides a sono-activatable hydrogel platform for precise sono-immunotherapy against GBM.
Topics & Concepts
ProdrugImmunotherapySelf-healing hydrogelsGliomaTumor microenvironmentCancer researchChemistryImmunogenic cell deathImmune systemMedicineImmunologyBiochemistryTumor cellsOrganic chemistryNanoplatforms for cancer theranosticsCerebrospinal fluid and hydrocephalusAnesthesia and Neurotoxicity Research