An allosteric inhibitor of bacterial Hsp70 chaperone potentiates antibiotics and mitigates resistance
Jordan Hosfelt, Aweon Richards, Meng Zheng, Carolina Adura, Brock Nelson, Amy Yang, Allison Fay, William Resager, Beatrix Ueberheide, J. Fraser Glickman, Tania J. Lupoli
Topics & Concepts
Chaperone (clinical)ChaperoninAllosteric regulationBiologyCofactorMycobacterium tuberculosisHsp70MicrobiologyProteostasisFoldaseBiochemistryGroELProtein foldingCell biologyHeat shock proteinEnzymeTuberculosisEscherichia coliMedicineGenePathologyHeat shock proteins researchComputational Drug Discovery MethodsEnzyme Structure and Function