Identifying lncRNA–miRNA–mRNA networks to investigate Alzheimer’s disease pathogenesis and therapy strategy
Nana Ma, Changrui Tie, Bo Yu, Wei Zhang, Jun Wan
Abstract
). This study presents the first systematic dissection of lncRNA-associated ceRNA profiles in the APP/PS1 mouse brain. The identified lncRNA-associated ceRNA networks could provide insights that facilitate AD diagnosis and future treatment strategies.
Topics & Concepts
Competing endogenous RNAmicroRNABiologyComputational biologyDiseaseLong non-coding RNANeuroinflammationDementiaBioinformaticsNeuroscienceRNAGeneGeneticsMedicinePathologyCancer-related molecular mechanisms researchMicroRNA in disease regulationCircular RNAs in diseases