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Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

Kenichi Shimada, Timothy R. Crother, Justin N. Karlin, Jargalsaikhan Dagvadorj, Norika Chiba, Shuang Chen, V. Krishnan Ramanujan, Andrea J. Wolf, Laurent Vergnes, David M. Ojcius, Altan Rentsendorj, Mario H. Vargas, Candace Guerrero, Yinsheng Wang, Katherine A. Fitzgerald, David M. Underhill, Terrence Town, Moshe Arditi

2012Immunity2,171 citationsDOIOpen Access PDF

Topics & Concepts

InflammasomeApoptosisMitochondrial DNACytosolMitochondrionCell biologyAIM2BiologyProgrammed cell deathMitochondrial ROSBiochemistryGeneReceptorEnzymeInflammasome and immune disordersinterferon and immune responsesImmune Response and Inflammation
Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis | Litcius