Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis
Kenichi Shimada, Timothy R. Crother, Justin N. Karlin, Jargalsaikhan Dagvadorj, Norika Chiba, Shuang Chen, V. Krishnan Ramanujan, Andrea J. Wolf, Laurent Vergnes, David M. Ojcius, Altan Rentsendorj, Mario H. Vargas, Candace Guerrero, Yinsheng Wang, Katherine A. Fitzgerald, David M. Underhill, Terrence Town, Moshe Arditi
Topics & Concepts
InflammasomeApoptosisMitochondrial DNACytosolMitochondrionCell biologyAIM2BiologyProgrammed cell deathMitochondrial ROSBiochemistryGeneReceptorEnzymeInflammasome and immune disordersinterferon and immune responsesImmune Response and Inflammation