Synthesis and Intramolecular Cyclization of Substituted 4-(Het)aryl-4-oxo-2-thienylaminobut-2-enoic Acids Containing Nitrile Group in the Thiophene Ring
I. A. Gorbunova, D. A. Shipilovskikh, А. Е. Рубцов, Sergei A. Shipilovskikh
Abstract
Abstract A method for the synthesis of substituted 4-(het)aryl-4-oxo-2-thienylaminobut-2-enoic acids containing a nitrile substituent in the thiophene ring was proposed. Intramolecular cyclization of the obtained compounds in the presence of propionic anhydride leads to the formation of new substituted 3-thienylimino-3H-furan-2-ones.
Topics & Concepts
ChemistryNitrileThiopheneSubstituentRing (chemistry)Intramolecular forceFuranArylMedicinal chemistryStereochemistryOrganic chemistryAlkylChemical synthesis and pharmacological studiesSynthesis of heterocyclic compoundsSynthesis and Reactions of Organic Compounds