Recent Advances in Synthesis and Medicinal Evaluation of 1,2‐Benzothiazine Analogues
Reetu Reetu, Raghuram Gujjarappa, Chandi C. Malakar
Abstract
Abstract Benzothiazines are one of the significant nitrogen containing heterocyclic scaffolds which are found to be multipurpose in the fields of drug discovery and medicinal chemistry. They are realized to be effective in curing enzymatic diseases caused by COX‐2, ALR‐2 (Aldose reductase enzyme), ALP (Alkaline phosphatase), 11β‐HSD 1 (11β‐hydroxysteroid dehydrogenase type 1) and proteolytic enzyme. These motifs act as a worthy candidate against cancerous cells, microorganisms, reactive oxygen species (ROS), viruses (HIV‐1, HCV‐NS5B) and monoamine oxidases. The objective of this review is to shed lime light on the medicinal and pharmacological aspects of 1,2‐benzothiazine derivatives which have been discovered in recent times for the benefit of broad range of readers in chemistry fraternity