Cancer-associated fibroblasts-derived exosomal miR-17-5p promotes colorectal cancer aggressive phenotype by initiating a RUNX3/MYC/TGF-β1 positive feedback loop
Yue Zhang, Shanci Wang, Qiuhua Lai, Yuxin Fang, Changjie Wu, Yongfeng Liu, Qingyuan Li, Xinke Wang, Chun-Cai Gu, Junsheng Chen, Jianqun Cai, Aimin Li, Side Liu
Topics & Concepts
Cancer researchStromal cellCancer-Associated FibroblastsOncogeneMicrovesiclesTransforming growth factorAutocrine signallingMetastasisBiologyTumor microenvironmentTumor progressionCancerColorectal cancermicroRNACell cultureCell biologyCell cycleGeneGeneticsTumor cellsExtracellular vesicles in diseaseCell Adhesion Molecules ResearchCancer-related molecular mechanisms research