Potassium <i>tert</i>-butoxide promoted regioselective deuteration of pyridines
Yan Li, Chenxu Zheng, Zhi‐Jiang Jiang, Jianbo Tang, Bencan Tang, Zhanghua Gao
Abstract
, replenishing the prevailing α-deuteration of the pyridine systems. Preliminary mechanistic studies suggested that the dimsyl carbanion acts as one of the key intermediates.
Topics & Concepts
RegioselectivityCarbanionChemistryPotassiumPyridineMedicinal chemistryCombinatorial chemistryOrganic chemistryCatalysisChemical Reactions and IsotopesCoordination Chemistry and OrganometallicsAsymmetric Hydrogenation and Catalysis