Rhodium‐Catalyzed Direct Vinylene Annulation of Sulfoxonium Ylides and <i>N</i>‐carbamoylindoles with Vinylene Carbonate
Jia‐Lin Song, Lin Xiao, Shaoyong Chen, Yi‐Chuan Zheng, Yanzhi Liu, Shang‐Shi Zhang, Bing Shu
Abstract
Abstract In this study, Rh(III)‐catalyzed C−H bifunctionalization and direct vinylene annulation of sulfoxonium ylides and N ‐carbamoylindoles with vinylene carbonate was accomplished, which afforded a series of naphthalenones containing a β‐ketosulfoxonium ylide moiety, isocoumarins, and pyrimidones. This protocol featured mild conditions, broad substrate scope, and functional‐groups compatibility. In addition, related applications and preliminary mechanistic exploratory were also investigated magnified image
Topics & Concepts
AnnulationChemistryYlideRhodiumCatalysisMoietyCarbonateIsocoumarinsCombinatorial chemistryOrganic chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCyclopropane Reaction Mechanisms