Polydopamine nanospheres coated with bovine serum albumin permit enhanced cell differentiation: fundamental mechanism and practical application for protein coating formation
Behafarid Ghalandari, Youyi Yu, Farnaz Ghorbani, Antony R. Warden, Khan Zara Ahmad, Xiao Sang, Shiyi Huang, Yu Zhang, Wenqiong Su, Adeleh Divsalar, Xianting Ding
Abstract
electrostatic forces. Notably, the protein coating modified PDANS surface enhances cell adhesion and proliferation as well as osteogenic differentiation. Such an enhancement is attributed to complementary surface properties provided by the dynamic PDANS-BSA complex and regular structure caused by BSA-BSA interactions in protein coating formation. This study provides a fundamental understanding of the molecular mechanism of protein coating formation, which facilitates the further development of functional protein-coated nanomaterials and guides the bioengineering decision making for biomedical applications, especially in bone tissue engineering.