The structure-based optimization of δ-sultone-fused pyrazoles as selective BuChE inhibitors
Ziwen Zhang, Jingli Min, Mengdie Chen, Xia Jiang, Yingying Xu, Hua‐Li Qin, Wenjian Tang
Topics & Concepts
ChemistryLipophilicityBenzylamineButyrylcholinesteraseSelectivityAchéIC50PyrazoleStereochemistryAcetylcholinesterasePotencyStructure–activity relationshipEnzymeCombinatorial chemistryBiochemistryOrganic chemistryIn vitroCatalysisCholinesterase and Neurodegenerative DiseasesChemical synthesis and alkaloidsPhosphodiesterase function and regulation