Membrane-tethered activation design of a photosensitizer boosts systemic antitumor immunity<i>via</i>pyroptosis
Pei Lu, Xianjun Liu, Xia Chu, Fenglin Wang, Jian‐Hui Jiang
Abstract
The membrane-tethered activation design of a new phenylbenzopyrylium photosensitizer (PS) with zwitterionic lipid pendants that allows long-lasting fluorogenic imaging of tumors, persistent photodynamic therapy and systemic anti-tumor immunity.
Topics & Concepts
PyroptosisPhotosensitizerImmunityChemistryCrosstalkMembraneBiophysicsCell biologyImmune systemMedicineBiologyImmunologyBiochemistryApoptosisPhotochemistryProgrammed cell deathPhysicsOpticsInflammasome and immune disordersImmunotherapy and Immune ResponsesImmune Response and Inflammation