A prime editor mouse to model a broad spectrum of somatic mutations in vivo
Zackery A. Ely, Nicolas Mathey‐Andrews, Santiago Naranjo, Samuel I. Gould, Kim L. Mercer, Gregory A. Newby, Christina M. Cabana, William M. Rideout, Grissel Cervantes-Jaramillo, Jennifer Khirallah, Katie Holland, Peyton B. Randolph, William A. Freed-Pastor, Jessie R. Davis, Zachary Kulstad, Peter M.K. Westcott, Lin Lin, Andrew V. Anzalone, Brendan Horton, Nimisha B. Pattada, Sean-Luc Shanahan, Zhongfeng Ye, Stefani Spranger, Qiaobing Xu, Francisco J. Sánchez‐Rivera, David R. Liu, Tyler Jacks
Topics & Concepts
Somatic cellBroad spectrumPrime (order theory)Spectrum (functional analysis)BiologyIn vivoGeneticsVirologyComputational biologyChemistryPhysicsMathematicsGeneCombinatoricsCombinatorial chemistryQuantum mechanicsCRISPR and Genetic EngineeringCancer Genomics and DiagnosticsSingle-cell and spatial transcriptomics