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A STUB1–CHIC2 complex inhibits CD8+ T cells to restrain tumor immunity

Martin W. LaFleur, Lauren E. Milling, P. T. Prathima, Vivian Li, Ashlyn M. Lemmen, Ivy S. L. Streeter, Paul K S Heisig, Nicole M. Derosia, Elizabeth Riffo, Haonan Xu, Thao H. Nguyen, Aashiya Kolengaden, Samuel C. Markson, John G. Doench, Arlene H. Sharpe

2025Nature Immunology10 citationsDOIOpen Access PDF

Topics & Concepts

BiologyCytotoxic T cellCD8Cell biologyCytokineCancer researchImmunologyImmune systemIn vitroBiochemistryCancer Immunotherapy and BiomarkersImmunotherapy and Immune ResponsesCAR-T cell therapy research
A STUB1–CHIC2 complex inhibits CD8+ T cells to restrain tumor immunity | Litcius