Bacteriophage Treatment Rescues Mice Infected with Multidrug-Resistant Klebsiella pneumoniae ST258
Shayla Hesse, Natalia Małachowa, Adeline R. Porter, Brett A. Freedman, Scott D. Kobayashi, Donald J. Gardner, Dana Scott, Sankar Adhya, Frank R. DeLeo
Abstract
(sequence type 258 [ST258]) bacteremia in a murine infection model. Moreover, we compare outcomes among three distinct phage treatment groups and identify potential correlates of therapeutic phage efficacy. These findings constitute an important first step toward optimizing and assessing phage therapy's potential for the treatment of severe ST258 infection in humans.
Topics & Concepts
Klebsiella pneumoniaeBacteriophageMultiple drug resistanceRefractory (planetary science)Phage therapyMicrobiologyMedicineVirologyDrug resistanceBiologyEscherichia coliGeneAstrobiologyBiochemistryBacteriophages and microbial interactionsAntibiotic Resistance in BacteriaViral gastroenteritis research and epidemiology