The Interaction Between N6-Methyladenosine Modification and Non-Coding RNAs in Gastrointestinal Tract Cancers
Yao Lin, Changfeng Man, Rong He, Lian He, Jiabin Huang, Shouyan Xiang, Zhe Dai, Xiaoyan Wang, Yu Fan
Abstract
N 6 -methyladenosine (m 6 A) is the most common epigenetic modification of eukaryotic RNA, which can participate in the growth and development of the body and a variety of physiological and disease processes by affecting the splicing, processing, localization, transport, translation, and degradation of RNA. Increasing evidence shows that non-coding RNAs, particularly microRNA, long non-coding RNA, and circular RNA, can also regulate the RNA m 6 A modification process by affecting the expression of m 6 A-related enzymes. The interaction between m 6 A modification and non-coding RNAs provides a new perspective for the exploration of the potential mechanism of tumor genesis and development. In this review, we summarize the potential mechanisms and effects of m 6 A and non-coding RNAs in gastrointestinal tract cancers.