Tumor oxygen microenvironment-tailored electron transfer-type photosensitizers for precise cancer therapy
Yiting Yang, Yafu Wang, Yang Liu, Kui Wang, Ge Wang, Yonggang Yang, Won Jun Jang, Tony D. James, Juyoung Yoon, Hua Zhang
Abstract
A novel therapeutic strategy using photosensitive dyes (Ser-TPAs) has been developed, resulting in sustained high concentrations of strongly oxidizing substances in cancer cells through the synergistic activation of electron transfer-type reactions.
Topics & Concepts
Oxidizing agentElectron transferChemistryPhotodynamic therapyCancer therapyTumor microenvironmentReactive oxygen speciesCancer cellOxygenPhotochemistryCancerBiophysicsCancer researchCombinatorial chemistryTumor cellsBiochemistryBiologyMedicineOrganic chemistryInternal medicineNanoplatforms for cancer theranosticsPorphyrin and Phthalocyanine ChemistryAdvanced biosensing and bioanalysis techniques