Interleukin-6 compared to the other Th17/Treg related cytokines in inflammatory bowel disease and colorectal cancer
Tsvetelina Velikova, Lyuba Miteva, Noyko Stanilov, Zoya Spassova, Spaska Stanilova
Abstract
BACKGROUND: The connection between inflammatory bowel disease (IBD) and colorectal cancer (CRC) is well-established, as persistent intestinal inflammation plays a substantial role in both disorders. Cytokines may further influence the inflammation and the carcinogenesis process. AIM: To compare cytokine patterns of active IBD patients with early and advanced CRC. METHODS: Choosing a panel of cytokines crucial for Th17/Treg differentiation and behavior, in colon specimens, as mRNA biomarkers, and their serum protein levels. RESULTS: alone in advanced CRC. The protein levels of the cytokines were significantly higher in CRC patients compared to IBD patients. CONCLUSION: could be a potential drug target for IBD and prevention of CRC development as well.