Development and characterization of amphotericin B nanoemulsion-loaded mucoadhesive gel for treatment of vulvovaginal candidiasis
Mrunal Patil, Amarjitsing Rajput, Veena Belgamwar, Shailesh S. Chalikwar
Abstract
vaginal lavage studies revealed that AmB-NE gel permeated 7.03-fold more than AmB-coarse gel. Prepared AmB-NE gel was stable in refrigerated condition and showed no histopathological toxicity. Thus, the present study suggests that AmB-NE gel could eliminate the existing problem of AmB and that it could serve as an alternative option to treat vulvovaginal candidiasis.
Topics & Concepts
Amphotericin BPermeationEx vivoIn vivoChromatographyGel permeation chromatographyMaterials scienceChemistryIn vitroMicrobiologyAntifungalMembraneOrganic chemistryPolymerBiologyBiochemistryBiotechnologyAdvancements in Transdermal Drug DeliveryDermatology and Skin DiseasesEssential Oils and Antimicrobial Activity