Rh(III)-Catalyzed Regioselective Annulations of 3-Arylisoxazolones and 3-Aryl-1,4,2-dioxazol-5-ones with Propargyl Alcohols: Access to 4-Arylisoquinolines and 4-Arylisoquinolones
Tongtong Wang, Hai‐Shan Jin, Manman Cao, Rubing Wang, Li‐Ming Zhao
Abstract
The Rh(III)-catalyzed dual directing group assisted C-H activation/annulation of 3-arylisoxazolones with propargyl alcohols has been developed, which expands the application scope of isoxazolones in organic synthesis. This protocol also worked well with 3-aryl-1,4,2-dioxazol-5-ones to produce synthetically and biologically important 4-arylisoquinolones.
Topics & Concepts
PropargylChemistryAnnulationRegioselectivityArylCatalysisCombinatorial chemistryFunctional groupMedicinal chemistryOrganic chemistryAlkylPolymerCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsSynthesis and Catalytic Reactions