RANKL and RANK in Cancer Therapy
Masahiro Onji, Josef Penninger
Abstract
Receptor activator of nuclear factor-κB (RANK) and its ligand (RANKL) are key regulators of mammalian physiology such as bone metabolism, immune tolerance and antitumor immunity, and mammary gland biology. Here, we explore the multiple functions of RANKL/RANK in physiology and pathophysiology and discuss underlying principles and strategies to modulate the RANKL/RANK pathway as a therapeutic target in immune-mediated cancer treatment.
Topics & Concepts
RANKLImmune systemActivator (genetics)RANK LigandReceptorBiologyCancerImmunologyCancer researchBioinformaticsGeneticsBone Metabolism and DiseasesNF-κB Signaling PathwaysCytokine Signaling Pathways and Interactions