Catestatin improves insulin sensitivity by attenuating endoplasmic reticulum stress: <i>In vivo</i> and <i>in silico</i> validation
Abhijit Dasgupta, Gautam Bandyopadhyay, Indrani Ray, Keya Bandyopadhyay, Nirmalya Chowdhury, Rajat K. De, Sushil K. Mahata
Abstract
experiment validated the simulation results by depicting that CST caused decrease in phosphorylation of UPR signaling molecules and increased phosphorylation of insulin signaling molecules. Besides simulation results predicted that enhancement of AKT phosphorylation helps in both overcoming ER stress and achieving insulin sensitivity. These effects of CST were verified in hepatocyte culture model.
Topics & Concepts
Endoplasmic reticulumIn silicoIn vivoInsulin sensitivitySensitivity (control systems)Unfolded protein responseInsulinStress (linguistics)Computational biologyChemistryCell biologyMedicineInsulin resistancePharmacologyInternal medicineBioinformaticsBiologyBiochemistryBiotechnologyEngineeringPhilosophyLinguisticsElectronic engineeringGeneEndoplasmic Reticulum Stress and DiseasePancreatic function and diabetesSirtuins and Resveratrol in Medicine