Calculation of an Apical Efflux Ratio from P-Glycoprotein (P-gp) In Vitro Transport Experiments Shows an Improved Correlation with In Vivo Cerebrospinal Fluid Measurements in Rats: Impact on P-gp Screening and Compound Optimization
Holger Fischer, Claudia Senn, Mohammed Ullah, Carina Cantrill, Franz Schuler, Li Yu
Topics & Concepts
EffluxIn vivoP-glycoproteinTranscellularIn vitroChemistryParacellular transportCerebrospinal fluidLipophilicityTransporterApical membranePermeability (electromagnetism)PharmacologyBiophysicsCell biologyBiochemistryInternal medicineBiologyMembraneMedicineBiotechnologyMultiple drug resistanceGeneAntibioticsDrug Transport and Resistance MechanismsPharmacological Effects and Toxicity StudiesTrace Elements in Health