One-Pot Photocascade Catalysis: Access to Pyrrole Derivatives from <i>N</i>-Arylglycines and Morita–Baylis–Hillman (MBH) Acetates
Jie Huang, Si-Yu You, Ling-Zhi Hu, Yan‐Hong He, Zhi Guan
Abstract
The step-economical synthesis of pyrrole derivatives has posed a challenge in the field of N -heterocyclic chemistry. A novel photocascade catalytic radical S N 2′-type reaction/radical addition/annulation sequence of MBH acetates provides a straightforward route to pyrrole derivatives by forming new C–C, C–N, and C═C bonds in one pot, using N -arylglycines as the α-arylaminomethyl radical precursors for double insertion.
Topics & Concepts
ChemistryPyrroleMorita therapyCatalysisBaylis–Hillman reactionMedicinal chemistryOrganic chemistryStereochemistryCombinatorial chemistryPure mathematicsMathematicsFluorine in Organic ChemistryRadical Photochemical ReactionsOxidative Organic Chemistry Reactions