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Cell fitness screens reveal a conflict between LINE-1 retrotransposition and DNA replication

Daniel Ardeljan, Jared P. Steranka, Chunhong Liu, Zhi Li, Martin S. Taylor, Lindsay M. Payer, Mikhail Gorbounov, Jacob S. Sarnecki, Vikram Deshpande, Ralph H. Hruban, Jef D. Boeke, David Fenyö, Pei-Hsun Wu, Agata Smogorzewska, Andrew J. Holland, Kathleen H. Burns

2020Nature Structural & Molecular Biology142 citationsDOIOpen Access PDF

Topics & Concepts

BiologyRetrotransposonDNA replicationCell cultureCell biologyGeneticsDNA re-replicationViral replicationDNA replication factor CDT1Licensing factorControl of chromosome duplicationDNAGeneGenomeTransposable elementChromosomal and Genetic VariationsPlant Virus Research StudiesCRISPR and Genetic Engineering
Cell fitness screens reveal a conflict between LINE-1 retrotransposition and DNA replication | Litcius