Auxiliary-controlled regiodivergent NiH-catalyzed <i>gem</i>-difluoroallylation of alkenyl amines <i>via</i> defluorinative olefin cross-coupling
Lin Zhu, Jie Huang, Fanling Meng, Ziyun Tan, Meng Xiao, Yang Xiao, Lanlan Zhang, Wenyi Li, Chao Wang
Abstract
A NiH-catalyzed migratory and non-migratory multisite-selective gem -difluoroallylation of alkenyl amines with trifluoromethyl alkenes has been developed by judicious choice of directing groups with high levels of chemo- and regioselectivity.
Topics & Concepts
ChemistryRegioselectivityOlefin fiberTrifluoromethylCatalysisCoupling (piping)Medicinal chemistryStereochemistryOrganic chemistryMechanical engineeringAlkylEngineeringFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsRadical Photochemical Reactions