A redox-sensitive core-crosslinked nanosystem combined with ultrasound for enhanced deep penetration of nanodiamonds into tumors
Meixuan Li, Qianyan Li, Wei Hou, Jingni Zhang, Hemin Ye, Huanan Li, Deping Zeng, Jin Bai
Abstract
enlarged tumor vascular endothelium cell gaps. As expected, the nanosystem combined with ultrasound can enhance anti-tumor efficacy with deep penetration and excellent retention performance in a HepG2 xenograft mouse model. This study highlights the ability of the integrated therapeutic paradigm to overcome the limitation of nanodiamonds and the potential for further application in cancer therapy.
Topics & Concepts
RedoxPenetration (warfare)NanodiamondCore (optical fiber)Materials scienceChemistryNanotechnologyOrganic chemistryComposite materialEngineeringDiamondOperations researchNanoparticle-Based Drug DeliveryDiamond and Carbon-based Materials ResearchNanoplatforms for cancer theranostics