A Family of T6SS Antibacterial Effectors Related to l,d-Transpeptidases Targets the Peptidoglycan
Stephanie Sibinelli‐Sousa, Julia Takuno Hespanhol, Gianlucca Gonçalves Nicastro, Bruno Y. Matsuyama, Stéphane Mesnage, Ankur Patel, Robson Francisco de Souza, Cristiane Rodrigues Guzzo, Ethel Bayer‐Santos
Abstract
by a non-canonical d-amino acid. Phylogenetic analysis shows that Tlde1 homologs constitute a family of T6SS-associated effectors broadly distributed among Proteobacteria. This work expands our current knowledge about bacterial effectors used in interbacterial competition and reveals a different mechanism of bacterial antagonism.
Topics & Concepts
PeptidoglycanEffectorCell envelopeType VI secretion systemPeriplasmic spaceBiologySecretionBiochemistryBacterial cell structureMicrobiologyCell biologyBacteriaChemistryCell wallGeneticsEscherichia coliGeneVirulenceVibrio bacteria research studiesEscherichia coli research studiesBacterial Genetics and Biotechnology