Engineering CAR-T cells for radiohapten capture in imaging and radioimmunotherapy applications
Keifer G. Kurtz, Laura Eibler, Megan M. Dacek, Lukas M. Carter, Darren R. Veach, Samantha Lovibond, Emma Reynaud, Sarah Qureshy, Michael R. McDevitt, Christopher M. Bourne, Sébastien Monette, Blesida Punzalan, Shireen Khayat, Svena Verma, Adam Kesner, Nai‐Kong V. Cheung, Heiko Schöder, Leah Gajecki, Sarah M. Cheal, Steven M. Larson, David A. Scheinberg, Simone Krebs
Abstract
Thor-cells are a new theranostic agent that may provide crucial information for better and safer clinical protocols of adoptive T cell therapies, as well as accelerated development strategies.
Topics & Concepts
BiodistributionIn vivoCytotoxic T cellCancer researchCell therapyMolecular imagingAdoptive cell transferRadioimmunotherapyChemistryIn vitroCellMedicineImmunologyBiologyMonoclonal antibodyAntibodyBiochemistryBiotechnologyCAR-T cell therapy researchVirus-based gene therapy researchNanowire Synthesis and Applications