A BODIPY-<i>O</i>-glycoside based near-infrared fluorescent sensor for serum albumin
Neelam Shivran, Mrunesh Koli, Goutam Chakraborty, Amit P. Srivastava, Subrata Chattopadhyay, Soumyaditya Mula
Abstract
-glycoside dyes. The BDP-Glu-NPs were characterized by spectroscopic, NMR, DLS and TEM studies. The ability of the BDP-Glu-NPs for the detection and quantification of serum albumin was demonstrated. It showed a 150-fold fluorescence enhancement in the presence of serum albumin, with excellent selectivity over other amino acids, porphyrin, proteins and various inorganic salts. Detection of human serum albumin (HSA) in urine samples showed that the bioprobe is applicable to a clinically significant range of the analytes with very low detection limit. These results suggested that the BDP-Glu-NPs can act as potential bioprobe to quantify albumin in biochemical and clinical samples.