Discovery of CN0 as a novel proteolysis-targeting chimera (PROTAC) degrader of PARP1 that can activate the cGAS/STING immunity pathway combined with daunorubicin
Shanshan Lin, Guihui Tu, Zelei Yu, Qingna Jiang, Lingyu Zhang, Jingwen Liu, Quanyu Liu, Xiuwang Huang, Jianhua Xu, Youwen Lin, Yang Liu, Lixian Wu
Topics & Concepts
PARP1ChemistryDaunorubicinDNA repairCell biologyInnate immune systemPoly ADP ribose polymeraseBiochemistryPolymeraseDNABiologyLeukemiaGeneticsReceptorProtein Degradation and InhibitorsPARP inhibition in cancer therapyinterferon and immune responses