CLEC-2-dependent platelet subendothelial accumulation by flow disturbance contributes to atherogenesis in mice
Chaojun Tang, Lei Wang, Yulan Sheng, Zhong Zheng, Zhanli Xie, Fan Wu, Tao You, Lijie Ren, Lijun Xia, Changgeng Ruan, Li Zhu
Abstract
Our results reveal a new CLEC-2-dependent platelet subendothelial accumulation in response to d-flow to regulate vascular inflammation.
Topics & Concepts
PlateletImmunostainingMonocyteChemistryMacrophageInflammationPathologyKnockout mousePlatelet activationFlow cytometryCell biologyReceptorEndocrinologyInternal medicineImmunologyBiologyMedicineImmunohistochemistryIn vitroBiochemistryAtherosclerosis and Cardiovascular DiseasesPlatelet Disorders and TreatmentsInflammatory Biomarkers in Disease Prognosis