Gata2 heterozygous mutant mice exhibit reduced inflammatory responses and impaired bacterial clearance
Jun Takai, Takashi Shimada, Tadaho Nakamura, James Douglas Engel, Takashi Moriguchi
Abstract
mice after cecal ligation and puncture-induced polymicrobial peritonitis. These results provide direct molecular insights into GATA2-directed host defenses and the pathogenic mechanisms underlying observed immunodeficiencies in GATA2-haploinsufficient patients.
Topics & Concepts
HaploinsufficiencyImmunologyBiologyGATA2HaematopoiesisInflammationDysbiosisGeneticsStem cellPhenotypeGeneGut floraImmunodeficiency and Autoimmune DisordersCystic Fibrosis Research AdvancesPneumocystis jirovecii pneumonia detection and treatment