Exaggerated inflammatory response to bacterial products in decompensated cirrhotic patients is orchestrated by interferons IL-6 and IL-8
Victoria Kronsten, Charlotte Woodhouse, Ane Zamalloa, Tiong Yeng Lim, Lindsey Edwards, Marc Martínez‐Llordella, Alberto Sánchez‐Fueyo, Debbie L. Shawcross
2022American Journal of Physiology-Gastrointestinal and Liver Physiology20 citationsDOIOpen Access PDF
Abstract
Decompensated cirrhotic patients, compared with compensated patients, exhibit a greater exaggerated inflammatory response to bacterial products orchestrated by interferons, IL-6, and IL-8. Postbacterial product stimulation levels of a number of pro-inflammatory cytokines negatively correlate with liver disease severity biomarkers and liver disease severity scores raising the possibility that the switch to an immunodeficient phenotype in cirrhosis-associated immune dysfunction may commence earlier in the course of advanced liver disease.
Topics & Concepts
Proinflammatory cytokineImmune systemCirrhosisImmunologyLipopolysaccharideMedicinePeripheral blood mononuclear cellStimulationCytokineInterferonLiver diseaseInflammationBiologyInternal medicineIn vitroBiochemistryLiver Disease and TransplantationLiver Disease Diagnosis and TreatmentHepatitis Viruses Studies and Epidemiology