The mechanism of full activation of tumor suppressor PTEN at the phosphoinositide-enriched membrane
Hyunbum Jang, Iris Nira Smith, Charis Eng, Ruth Nussinov
Abstract
. Finally, we determined PTEN catalytic action at the membrane, all in line with experimental observations, deciphering the mechanisms of how PTEN anchors to the membrane and restrains cancer.
Topics & Concepts
PTENCytosolPhosphatidylserinePhosphataseCell biologyChemistryPI3K/AKT/mTOR pathwaySuppressorMembranePleckstrin homology domainPhosphatidylinositolSignal transductionPhosphorylationBiochemistryBiologyPhospholipidEnzymeGenePI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase SignalingCellular transport and secretion