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Biological applications of lipoic acid-based polymers: an old material with new promise

Qing Yu, Zhiyue Fang, Shifang Luan, Lei Wang, Hengchong Shi

2024Journal of Materials Chemistry B38 citationsDOIOpen Access PDF

Abstract

ring-opening polymerization (ROP). Herein, we first summarize disulfide-mediated ROP polymerization strategies, providing basic routes for designing and preparing PLA-based materials. PLA, as a biologically derived, low toxic, and easily modified material, possesses dynamic disulfide bonds and universal non-covalent carboxyl groups. We also shed light on the biomedical applications of PLA-based materials based on their biological and structural features and further divide recent works into six categories: antibacterial, anti-inflammation, anticancer, adhesive, flexible electronics, and 3D-printed tissue scaffolds. Finally, the challenges and future prospects associated with the biomedical applications of PLA are discussed.

Topics & Concepts

Lipoic acidMaterials sciencePolymerNanotechnologyPolymer scienceComposite materialOrganic chemistryChemistryAntioxidantBiochemical Acid Research Studiesbiodegradable polymer synthesis and propertiesClick Chemistry and Applications
Biological applications of lipoic acid-based polymers: an old material with new promise | Litcius