Blueberry anthocyanins improve liver fibrosis by regulating NCOA4 ubiquitination through TRIM7 to affect ferroptosis of hepatic stellate cells
Likun Liu, Jinhui Du, Haiqing Fan, Yue Yu, Yilin Luo, Fang Gu, Hui Yu, Xin Liao
Abstract
This was the first study to demonstrate that anthocyanins can improve the progression of liver fibrosis by promoting hepatic stellate cell (HSC) ferroptosis. Anthocyanins could affect the content of Fe 2+ by promoting ferroautophagy in HSCs, thereby promoting the level of ferroptosis. This study demonstrates for the first time that anthocyanins can inhibit the expression of TRIM7 and then affect the ubiquitination of NCOA4 to regulate the level of ferritin autophagy and ferroptosis.
Topics & Concepts
AutophagyHepatic stellate cellUbiquitinAffect (linguistics)Cell biologyHepatic fibrosisFerritinFibrosisCellChemistryBiologyCancer researchBiochemistryInternal medicineApoptosisMedicineEndocrinologyPsychologyGeneCommunicationFerroptosis and cancer prognosisEndoplasmic Reticulum Stress and DiseaseCircular RNAs in diseases